General Information

  • ID:  hor001106
  • Uniprot ID:  NA
  • Protein name:  FMRFamide-related peptide
  • Gene name:  NA
  • Organism:  NA
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  XDYGHMRF
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Increase the frequency of spontaneous contractions of the larval mosquito heart and increased heart rate
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001106_AF2.pdbhor001106_ESM.pdb

Physical Information

Mass: 114205 Formula: C41H54N12O10S
Absent amino acids: ACEIKLNPQSTVW Common amino acids: DFGHMRYX
pI: 7.54 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -102.5 Boman Index: -2217
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index 0
Instability Index: -1253.75 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  12747944
  • Title:  The Structure of the FMRFamide Receptor and Activity of the Cardioexcitatory Neuropeptide Are Conserved in Mosquito